OBJECTIVE:While Grenada attained a zero-human-rabies case status since 1970, the authors conducted the first study to assess knowledge, attitudes, and practices that may contribute to this status as well as to receive feedback on the rabies control program in Grenada.METHODOLOGY:A cross-sectional survey was conducted in July, 2017 with 996 househol
Combining Isotopic Tracer Techniques to Increase Efficiency of Clinical Pharmacokinetic Trials in Oncology
Abstract With increasing numbers of drugs tested in oncology for smaller patient populations, fewer patients are available to answer important clinical pharmacological questions in the timeframe of clinical drug development.The quality and efficiency of trials to assess the pharmacokinetics of new drugs can be improved by making better use of avail
Effects of Daily Peat Smoke Exposure on Present and Next Generations
This study aimed to follow the neurotoxic effect of peat smoke on adult outbred rats and its influence on central nervous system (CNS) parameters in first-generation offspring.Under I.V. Dressings experimental conditions, exposure to peat smoke was carried out on adult male Wistar rats for 24 h.After the end of the exposure, an open field test (OFT
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition
Abstract Background Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality.Therapy resistance and significant side effects of current treatment strategies indicate the need for more effective POCKET SQUARES agents to treat both androgen-dependent and androgen-i